Antidepressant efficacy for major depressive disorder (MDD) remains limited, with the neural mechanisms underlying treatment response poorly understood. The default mode network (DMN), particularly ...

Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional ...

A new analysis explores the genetic liability of psychiatric disorders using polygenic scores and recurrent copy number variants.

Although antidepressants are a mainstay of MDD treatment, they are plagued by poor efficacy, high rates of relapse, and intolerable side effects. 40,41 Second-generation antidepressants, including ...